Opinion Paper Summarizing the Evaluation Tools Developed for Rett Syndrome

The evaluation of Rett Syndrome (RTT), as previously mentioned, is challenging due to the significant variability in clinical presentation and symptom burden. Several evaluation tools for different purposes have been developed, including to evaluate clinical severity, behavior, and functional motor abilities, however, it is challenging for clinicians to determine their practicality and application to patient care. This review and opinion article aims to provide an overview of these different tools, as well as how to apply them in order to improve and/or guide evaluation and management for RTT.

In addition, a potentially new tool, the Rett Syndrome Fear of Movement Scale (RSFMS) was recently proposed in a separate publication, which specifically looks at fear of movement (FOM), a key characteristic of RTT patients. More about these tools and recent publications can be found below.

  • Lotan, Meir, et al. “Evaluation Tools Developed for Rett Syndrome.” Diagnostics 13.10 (2023): 1708.
  • Lotan, Meir, Moti Zwilling, and Alberto Romano. “Psychometric Values of a New Scale: The Rett Syndrome Fear of Movement Scale (RSFMS).” Diagnostics 13.13 (2023): 2148.