Clinical Spotlight

Pediatric Diagnosis & Treatment for
Rett Syndrome

1-HOUR COMPLIMENTARY WEBCAST developed from a Symposium at the 2022 Pediatric Brain and Resilience Summit

Rett Syndrome is one of the most frequent causes of mental disability in females, with an estimated prevalence of 1 in 10,000 under the age of 12. It is characterized by normal early growth and development followed by a slowing of development, loss of purposeful use of the hands, distinctive hand movements, slowed brain and head growth, problems with walking, seizures, and intellectual disability.

Significant challenges remain in the screening, diagnosis, and treatment of this condition, stemming from overall limited awareness as well as limited treatment options. Several emerging therapeutics are in clinical development that could potentially lessen the impacts of this condition in the near future, and during this activity, experts will overview these advances, as well as share important clinical pearls on the burden, screening, and diagnosis of Rett Syndrome.

This activity is intended for physicians, physician assistant/associate, nurse practitioners, registered nurses and other healthcare providers who care for patients with Rett Syndrome.

CME/CE Credits Available:

• 1.0 AMA PRA Category 1 Credit(s)TM (Physician)
• 1 CNE Contact Hours (Nurses)

This activity is supported by an educational grant from Acadia Pharmaceuticals

Upon completion of the educational activity, participants should be able to:

  • Summarize the background of Rett Syndrome
  • Discuss the quality-of-life of pediatric patients who have Rett Syndrome
  • Recognize important considerations when providing a differential diagnosis in patients with Rett Syndrome
  • Describe the emerging treatment options for Rett Syndrome


David Lieberman, MD
  • Assistant, Neurobiology Departmant at Boston Children’s 
  • Instructor, Neurology at Harvard Medical School
Richard Haas, MD
  • Director of the Neurometabolic Clinic at Rady Children’s Hospital San Diego
  • Director of the Mitochondrial Disease Laboratory
  • Professor at UC San Diego School of Medicine